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Cortisol: a tool to study aldosterone biosynthesis in rats
L Matković1, C E Gomez-Sanchez, C P Lantos
1Departamento de Química Biológica, Facultad de Cs. Exactas y Naturales-UBA and PRHOM-CONICET, Buenos Aires, Argentina.
Endocrine Research
|February 1, 1995
Abstract:
Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F. competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B.