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Results of a prospective randomized trial using DTIC and interferon as adjuvant therapy for stage I malignant
M J Kerin1, P Gillen, J R Monson
1Department of Clinical Surgery, Meath/Adelaide Hospitals, Dublin, Ireland.
Abstract:
This prospective randomized trial evaluated the effect of DTIC and interferon as adjuvant therapy for high risk stage 1 malignant melanoma in 26 patients. Both groups were well matched for depth of disease, site of melanoma and other prognostic criteria. Like other studies the findings of 2.6 times increased relative risk of mortality in the treatment arm do not support a rationale for adjuvant immuno-chemotherapy even in patients at high risk of recurrence.

