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Cerebral malaria in Jabalpur, India

M M Shukla1, N Singh, M P Singh

  • 1Malaria Research Centre, (Field Station), Medical College Building, Jabalpur, India.

Indian Journal of Malariology
|June 1, 1995
PubMed
Summary

Cerebral malaria affected 8.5% of fever patients, with higher mortality in males and those with delayed treatment. Coma was a key factor in deaths from this severe malaria complication.

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Clinical Epidemiology

Background:

  • Malaria remains a significant public health concern, particularly in endemic regions.
  • Cerebral malaria is a severe, life-threatening complication of Plasmodium falciparum infection.
  • Understanding risk factors for mortality is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the incidence and mortality of cerebral malaria in a tertiary care hospital.
  • To identify demographic, clinical, and treatment-related factors associated with cerebral malaria mortality.
  • To determine the primary determinants of death in cerebral malaria patients.

Main Methods:

  • Retrospective analysis of 1783 patients admitted with fever.
  • Identification of cerebral malaria cases and analysis of demographic data.
  • Comparison of characteristics and outcomes between survivors and non-survivors.

Main Results:

  • Out of 1783 fever admissions, 152 (8.5%) had cerebral malaria, with a 25.6% mortality rate (39 deaths).
  • Males and the 16-40 years age group were predominantly affected.
  • Higher mortality was observed in patients with hyperparasitaemia, hypoglycaemia, and delayed diagnosis/treatment.

Conclusions:

  • Cerebral malaria poses a significant mortality risk, especially in males and younger adults.
  • Prompt diagnosis and treatment, alongside management of complications like coma, are critical for reducing mortality.
  • Hyperparasitaemia, hypoglycaemia, and delayed interventions are key indicators of poor prognosis.

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