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Related Experiment Videos

Massive chronic intervillositis associated with recurrent abortions

B J Doss1, M F Greene, J Hill

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Human Pathology
|November 1, 1995
PubMed
Summary

Massive chronic intervillositis (MCI), a rare placental lesion, was linked to recurrent pregnancy loss in a case study. This finding suggests MCI may be an identifiable cause of recurrent spontaneous abortions.

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Reference weights for placentas delivered before the 28th week of gestation.

Placenta·2007

Area of Science:

  • Reproductive immunology
  • Perinatal pathology

Background:

  • Massive chronic intervillositis (MCI) is an uncommon placental lesion.
  • MCI is typically associated with poor fetal growth and adverse pregnancy outcomes.
  • Previously, MCI was not linked to spontaneous abortion or recurrent pregnancy loss.

Observation:

  • This study details a patient experiencing 10 spontaneous abortions.
  • Massive chronic intervillositis was documented in 4 of 5 pregnancies across all trimesters.
  • Histology revealed extensive infiltration of the intervillous space by inflammatory cells and fibrin, without chronic villitis.

Findings:

  • The cellular infiltrate comprised primarily monocyte/macrophage populations (LCA+, CD68+, occasional CD45RO+).
  • Elevated maternal serum alpha-fetoprotein levels were noted in two pregnancies.

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  • These placental findings suggest a potential immunologic basis for MCI.

    • Implications:

    • Massive chronic intervillositis may be a histopathologically recognizable cause of recurrent spontaneous abortion.
    • Further research into the immunologic mechanisms of MCI is warranted.
    • This case expands the known clinical spectrum of massive chronic intervillositis.