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Left ventricular diastolic function in hypertension: a 4 year follow-up study
J Mayet1, M Shahi, N R Poulter
1Department of Cardiology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
International Journal of Cardiology
|June 30, 1995
Summary
Long-term antihypertensive treatment significantly reduced left ventricular mass and improved diastolic function in hypertensive patients. Prolonged therapy may reverse left ventricular diastolic dysfunction in hypertension.
Area of Science:
- Cardiology
- Hypertension Research
- Echocardiography
Background:
- Hypertension is associated with left ventricular diastolic dysfunction.
- Long-term effects of antihypertensive treatment on diastolic function require further investigation.
Purpose of the Study:
- To assess the long-term effects of antihypertensive treatment on left ventricular diastolic function.
Main Methods:
- Followed 26 hypertensive patients for a mean of 4.25 years.
- Utilized two-dimensional and Doppler echocardiography to evaluate left ventricular mass, isovolumic relaxation time (IVRT), and E/A ratio.
- Assessed changes at 9 months and 4.25 years of therapy.
Main Results:
- Significant reduction in left ventricular mass index observed after 9 months and maintained over 4.25 years.
- No initial change in IVRT or E/A ratio at 9 months.
- Significant improvement in IVRT after 4.25 years, with a trend towards improved E/A ratio; 12/14 patients with abnormal baseline IVRT normalized.
Conclusions:
- Prolonged antihypertensive treatment can lead to significant improvements in left ventricular diastolic function.
- Left ventricular diastolic dysfunction associated with hypertension may be reversible with sustained antihypertensive therapy.