Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes following overhydration with irrigating fluids

W Zhang1, R G Hahn, G You

  • 1Department of Anaesthesiology, Stockholm Södra Hospital, Sweden.

International Urology and Nephrology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maldistribution of fluid in preeclampsia: a secondary kinetic analysis.

International journal of obstetric anesthesia·2023
Same author

Knowledge, attitude, and practice regarding COVID-19 among healthcare workers in Henan, China.

The Journal of hospital infection·2020
Same author

Volume kinetics of Ringer's lactate solution in acute inflammatory disease.

British journal of anaesthesia·2018
Same author

Normal range for cytokines should be reported.

Acta anaesthesiologica Scandinavica·2018
Same author

Recruitment of extravascular fluid by hyperoncotic albumin.

Acta anaesthesiologica Scandinavica·2018
Same author

Spectrum and origin of mutations in sporadic cases of haemophilia A in China.

Haemophilia : the official journal of the World Federation of Hemophilia·2018

Hypo-osmotic irrigating fluids containing mannitol or sorbitol cause kidney and brain tissue damage in rabbits. Tissue damage depends on fluid osmolality, not the specific solute, with lungs unaffected by TUR syndrome.

Area of Science:

  • Nephrology
  • Neurology
  • Pathology

Background:

  • Transurethral resection (TUR) syndrome is a potential complication of urological procedures.
  • Irrigating fluids used in TUR can be absorbed, leading to systemic effects.
  • Understanding the effects of irrigating fluid composition and osmolality is crucial for patient safety.

Purpose of the Study:

  • To investigate the ultrastructural alterations in organs following intravenous infusion of irrigating fluids.
  • To determine the role of irrigating fluid osmolality and solute type (mannitol/sorbitol) in causing tissue damage.
  • To assess the potential involvement of the lung in the TUR syndrome.

Main Methods:

  • Intravenous infusion of irrigating fluid (150 ml/kg) with varying osmolalities (165-350 mosmol/kg) in 15 rabbits.

Related Experiment Videos

  • Electron microscopic examination of kidney, brain, and lung tissues.
  • Comparison of tissue damage induced by hypo-osmotic versus iso-osmotic solutions.

    • Main Results:

    • Hypo-osmotic solutions induced significant interstitial and cellular edema in kidney and brain tissues.
    • No significant tissue damage was observed with iso-osmotic irrigating fluid.
    • No ultrastructural changes were detected in lung tissue, irrespective of the irrigating fluid used.

    Conclusions:

    • Ultrastructural changes following irrigating fluid overhydration are dependent on the solution's osmolality, not the solute (mannitol or sorbitol).
    • Kidney and brain tissues are susceptible to damage from hypo-osmotic irrigating fluids.
    • The lung does not appear to be a primary target organ for the TUR syndrome.