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Related Experiment Videos

Long oestradiol replacement in an oocyte donation programme

J Remohí1, A Gutiérrez, F Cano

  • 1Instituto Valenciano de Infertilidad, Valencia University School of Medicine, Spain.

Human Reproduction (Oxford, England)
|June 1, 1995
PubMed
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Extending unopposed estrogen therapy beyond 35 days in egg donation programs did not affect pregnancy or implantation rates. However, breakthrough bleeding increased significantly after 9 weeks, suggesting a limit for prolonged estrogen use in IVF.

Area of Science:

  • Reproductive Medicine
  • Endocrinology
  • In Vitro Fertilization (IVF)

Background:

  • Endometrial receptivity is crucial for successful embryo implantation in IVF.
  • Optimizing estrogen administration protocols is key in assisted reproductive technologies.

Purpose of the Study:

  • To determine the optimal duration for unopposed estrogen administration in egg donation programs.
  • To evaluate the impact of prolonged estrogen therapy on endometrial receptivity and implantation rates.

Main Methods:

  • A study involving 186 egg recipients and 182 donors undergoing IVF.
  • Five groups received varying durations of oestradiol valerate (up to 6 mg/day) in a 'prolonged follicular phase' protocol.
  • Gonadotrophin-releasing hormone analogues (GnRHa) were used in ovulatory patients.

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Main Results:

  • No significant differences in pregnancy or implantation rates were observed across groups with varying estrogen administration durations.
  • Successful implantation occurred even after 100 days of unopposed estrogen therapy.
  • Breakthrough bleeding incidence increased with longer estrogen administration, exceeding 44% after 9 weeks.

Conclusions:

  • Prolonged estrogen replacement therapy in egg donation is feasible for up to 15 weeks.
  • Due to increased breakthrough bleeding, stopping estrogen treatment around 9 weeks is advisable in IVF protocols.