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Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis
D Y Leung1, J B Travers, R Giorno
1Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA.
The Journal of Clinical Investigation
|November 1, 1995
Summary
T cells, specifically V beta 2+ T cells, accumulate in guttate psoriasis lesions, suggesting streptococcal superantigens trigger this T cell response in skin infections.
Area of Science:
- Immunology
- Dermatology
- Microbiology
Background:
- Psoriasis pathogenesis involves T cells.
- Guttate psoriasis is linked to streptococcal infections.
- Superantigens may activate T cells in guttate psoriasis.
Purpose of the Study:
- Investigate T cell activation in guttate psoriasis.
- Determine the role of streptococcal superantigens.
- Analyze T cell receptor V beta repertoire in lesions.
Main Methods:
- Analyzed T cell receptor V beta repertoire in blood and skin biopsies.
- Used monoclonal antibodies for V beta families.
- Sequenced T cell receptor beta chain genes.
Main Results:
- Selective accumulation of V beta 2+ T cells in guttate psoriasis lesions.
- V beta 2+ T cell expansion observed in CD4+ and CD8+ subsets.
- Extensive junctional diversity suggests superantigenic stimulation.
Conclusions:
- Acute guttate psoriasis is associated with T cell superantigenic stimulation.
- Streptococcal superantigens likely trigger T cell responses in guttate psoriasis.
- Findings support a superantigen-driven mechanism in guttate psoriasis.
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