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Height and mortality after myocardial infarction

C R Rosenberg1, R E Shore, B S Pasternack

  • 1IPRO, Lake Success, NY 11042, USA.

Journal of Community Health
|August 1, 1995
PubMed
Summary

Short stature in men is linked to increased mortality risk, particularly from coronary heart disease. This association may stem from childhood factors influencing later-life health outcomes.

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Area of Science:

  • Cardiology
  • Epidemiology
  • Human Physiology

Background:

  • The Beta Blocker Heart Attack Trial (BHAT) provided a unique dataset for retrospective analysis.
  • Investigating non-traditional risk factors for cardiovascular disease mortality is crucial.

Purpose of the Study:

  • To examine the association between patient height and mortality within the BHAT cohort.
  • To determine if sex influences the relationship between height and mortality.

Main Methods:

  • A case-control analysis was performed on data from the completed Beta Blocker Heart Attack Trial (BHAT).
  • Relative risk (RR) was calculated for height reduction, controlling for relevant covariates.
  • Subgroup analyses were conducted based on sex and treatment allocation (propranolol).

Main Results:

  • A 4-inch reduction in height was associated with a relative risk (RR) of 1.18 for mortality (95% CI, 0.92 to 1.51).
  • The association between short stature and mortality was significant in males (RR 1.26, 95% CI 0.96 to 1.63) but not in females (RR 0.89, 95% CI 0.49 to 1.59).
  • In untreated males, the RR for mortality per 4-inch height reduction was 1.41 (95% CI 1.00 to 1.99).

Conclusions:

  • Short stature may serve as a marker for increased coronary heart disease mortality risk in men.
  • Childhood factors predisposing males to mortality from coronary heart disease later in life are hypothesized.
  • Further research is needed to elucidate the underlying mechanisms linking short stature to cardiovascular mortality.

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