Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Right-hemisphere dysfunction in Asperger's syndrome

J R McKelvey1, R Lambert, L Mottron

  • 1Department of Neurology/Neurosurgery, McGill University, Montreal, Quebec, Canada.

Journal of Child Neurology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a Visual Cognitive Style in Autism: A Cluster Analysis.

Journal of autism and developmental disorders·2024
Same author

Detrimental ''Sensitivity'' framework misses the positive performance, role and autonomy of autistic perception.

Cognitive neuroscience·2019
Same author

Gyrification changes are related to cognitive strengths in autism.

NeuroImage. Clinical·2018
Same author

Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

Journal of neurology·2017
Same author

Measurement properties of screening and diagnostic tools for autism spectrum adults of mean normal intelligence: A systematic review.

European psychiatry : the journal of the Association of European Psychiatrists·2017
Same author

Children born at 32 to 35 weeks with birth asphyxia and later cerebral palsy are different from those born after 35 weeks.

Journal of perinatology : official journal of the California Perinatal Association·2017
Same journal

Birmingham, 1963.

Journal of child neurology·2026
Same journal

Hyperintensity on Diffusion-Weighted Imaging in a MELAS Patient Does Not Necessarily Mean Cytotoxic Edema.

Journal of child neurology·2026
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
Same journal

Symptoms of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, and Autism Spectrum Disorder in Children and Adolescents Attending a Headache Outpatient Clinic and School-Based Controls.

Journal of child neurology·2026
Same journal

Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurology·2026
Same journal

The Cost of Fear for Pediatric Neurologic Care.

Journal of child neurology·2026
See all related articles

This study investigated Asperger's syndrome, finding evidence of abnormal right-hemisphere function using SPECT imaging. These results support the theory that Asperger's syndrome stems from a developmental issue in the right brain hemisphere.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Background:

  • Asperger's syndrome shares clinical features with acquired right-hemisphere dysfunction.
  • Previous research suggested a developmental abnormality of the right hemisphere in Asperger's syndrome but lacked neuroimaging evidence.

Observation:

  • Three patients diagnosed with Asperger's syndrome underwent neuroimaging, including computed tomographic (CT) scanning, magnetic resonance imaging (MRI), and single photon emission computed tomographic (SPECT) scanning.
  • While CT and MRI showed mild right hemispheric atrophy in one subject, the other two had normal results.
  • SPECT imaging revealed distinct right-hemisphere functional abnormalities in all three patients.

Findings:

  • SPECT scans indicated varied patterns of abnormal cerebral blood flow in the right hemisphere, including hypoperfusion and hyperperfusion in specific regions (temporal, frontal polar).

Related Experiment Videos

  • Abnormalities were also noted in the cerebellum, with variations in size and tracer uptake in the right hemisphere and vermis.
  • These functional and structural imaging findings provide direct evidence of right-hemisphere dysfunction in individuals with Asperger's syndrome.

    • Implications:

    • The study's findings support the hypothesis that Asperger's syndrome is associated with a developmental abnormality of the right cerebral hemisphere.
    • This research may guide future investigations into the neurobiological underpinnings of Asperger's syndrome and related neurodevelopmental disorders.
    • The results highlight the potential role of advanced neuroimaging techniques in understanding the pathophysiology of Asperger's syndrome.