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Papain-induced asthma--physiological and immunological features

H S Novey, L E Marchioli, W N Sokol

    The Journal of Allergy and Clinical Immunology
    |February 1, 1979
    PubMed
    Summary

    Papain dust exposure can cause occupational asthma in workers. This study found dual hypersensitivity reactions to papain, highlighting it as an asthma risk factor.

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    Area of Science:

    • Occupational Health
    • Immunology
    • Pulmonology

    Background:

    • Growing reports link papain exposure to respiratory issues.
    • Investigated a meat tenderizer factory supervisor with occupational asthma.

    Observation:

    • Symptoms worsened with papain dust exposure at work.
    • Symptoms improved during weekends and vacations.

    Findings:

    • Bronchial challenges confirmed papain-induced immediate and late asthma.
    • Detected specific IgE and precipitating antibodies, indicating dual Type I and III hypersensitivity.
    • Papain identified as the specific allergen.

    Implications:

    • Papain acts as an occupational allergen, posing an asthma risk.
    • Highlights the importance of allergen identification in occupational respiratory diseases.
    • Suggests papain exposure is a risk factor for asthma in non-tropical individuals.

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