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Malignant solid tumors in neonates: a 40-year review
H Xue1, J R Horwitz, M B Smith
1Division of Pediatric Surgery, University of Texas Medical School, Houston, USA.
Journal of Pediatric Surgery
|April 1, 1995
Summary
Neonatal solid tumors have a good prognosis in infants without distant metastatic disease. Early detection and treatment are crucial for improving survival rates in these rare pediatric cancers.
Area of Science:
- Pediatric Oncology
- Neonatal Medicine
- Cancer Research
Background:
- Neonatal malignant solid tumors are rare but aggressive pediatric cancers.
- Understanding outcomes is vital for improving treatment strategies.
Purpose of the Study:
- To evaluate the outcomes of neonatal malignant solid tumors.
- To identify prognostic factors for survival in affected infants.
Main Methods:
- Retrospective review of 222 infants (<1 year) with malignancies.
- Focus on 32 infants with neonatal solid tumors (<30 days old).
- Analysis of tumor types, sites, treatments, and survival rates.
Main Results:
- Common diagnoses included soft tissue sarcoma, neuroblastoma, and brain tumors.
- Most tumors presented at or within the first week of life.
- Overall survival was 78%, with no survivors among those with distant metastatic disease at diagnosis.
Conclusions:
- Prognosis for neonatal solid tumors is excellent in the absence of distant metastatic disease.
- Extracranial tumors, in particular, show a favorable outlook.
- Early diagnosis and intervention are critical for improving survival in neonatal malignancies.