Related Experiment Videos
Acute renal insufficiency in ibuprofen overdose
1Division of Gastroenterology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Pediatric Emergency Care
|April 1, 1995
Summary
Severe ibuprofen overdose in children can cause acute, reversible kidney injury. Monitoring renal function is crucial in pediatric ibuprofen toxicity cases.
Area of Science:
- Pediatric Nephrology
- Clinical Toxicology
- Pharmacovigilance
Background:
- Ibuprofen is a common nonprescription analgesic and anti-inflammatory drug.
- Large ingestions of ibuprofen (> 400 mg/kg) are associated with significant toxicity.
- Acute renal insufficiency is a known complication of ibuprofen overdose in adults, but rarely reported in children.
Observation:
- A healthy two-year-old boy ingested approximately 640 mg/kg of ibuprofen.
- The child developed acute renal insufficiency with rising creatinine levels and microscopic hematuria.
- Serum ibuprofen concentration was significantly elevated, indicating a toxic ingestion.
Findings:
- The pediatric case presented with reversible acute renal insufficiency following a severe ibuprofen overdose.
- Renal function normalized within 72 hours without complications.
- This case highlights a rare but significant adverse effect of ibuprofen in children.
Implications:
- Clinicians should consider monitoring renal function in children with significant ibuprofen overdose.
- This case expands the understanding of ibuprofen toxicity in pediatric populations.
- Prompt recognition and management can lead to full recovery of renal function.