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Cardiopulmonary bypass perfusion temperature does not influence perioperative renal function
I A Regragui1, M B Izzat, I Birdi
1Department of Cardiac Surgery, University of Bristol, United Kingdom.
The Annals of Thoracic Surgery
|July 1, 1995
Summary
Cardiopulmonary bypass (CPB) perfusion temperature does not impact renal function in patients undergoing coronary artery bypass grafting. This study found no significant differences in renal markers across various CPB temperatures.
Area of Science:
- Cardiovascular Surgery
- Nephrology
- Medical Physiology
Background:
- Concerns exist regarding renal dysfunction associated with normothermic cardiopulmonary bypass (CPB).
- CPB may exacerbate systemic inflammatory responses and end-organ injury.
- Investigating the impact of CPB temperature on renal function is crucial.
Purpose of the Study:
- To determine the influence of CPB perfusion temperature on renal function.
- To assess renal function at different CPB temperatures (28°C, 32°C, 37°C).
Main Methods:
- Prospective, randomized, controlled trial in 30 coronary artery bypass grafting patients.
- Measurement of creatinine clearance preoperatively, during CPB, and for 48 hours postoperatively.
- Assessment of glomerular and tubular function via urinary markers (creatinine, albumin, total protein, retinol binding protein).
Main Results:
- Creatinine clearance increased during CPB across all temperature groups.
- Urinary albumin/creatinine, total protein/creatinine, and retinol binding protein/creatinine ratios increased during CPB and postoperatively.
- No statistically significant differences in renal markers were observed between the three temperature groups.
Conclusions:
- Cardiopulmonary bypass perfusion temperature does not appear to influence renal function.
- Findings suggest renal function is not significantly affected by CPB temperature in this patient cohort.