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Diabetic neuropathy and the microcirculation

M D Flynn1, J E Tooke

  • 1Department of Diabetes and Endocrinology, Prince Philip Hospital, Llanelli, Dyfed, UK.

Diabetic Medicine : a Journal of the British Diabetic Association
|April 1, 1995
PubMed
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Diabetic neuropathy damages microcirculation through neurogenic factors, causing blood flow issues and inflammation. This contributes to microangiopathy and diabetic foot ulcers, with microvascular changes potentially worsening neuropathy.

Area of Science:

  • Diabetology
  • Neurology
  • Vascular Biology

Background:

  • Diabetic neuropathy is linked to impaired microcirculation.
  • Neurogenic factors are key regulators of microvascular function.

Purpose of the Study:

  • To explore the relationship between neurogenic control of microcirculation and diabetic neuropathy.
  • To understand the role of microvascular dysfunction in diabetic foot ulceration.

Main Methods:

  • Analysis of neurogenic mechanisms regulating microcirculation in diabetic subjects.
  • Investigation of haemodynamic disturbances and inflammatory responses.

Main Results:

  • Damage to neurogenic mechanisms causes significant haemodynamic disturbances.

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  • Increased arteriovenous shunting, abnormal postural blood flow regulation, and inflammation observed.
  • Abnormal microvascular haemodynamics contribute to microangiopathy and diabetic foot ulcer pathogenesis.

    • Conclusions:

    • Neurogenic dysregulation of microcirculation is central to diabetic neuropathy complications.
    • Microvascular abnormalities are implicated in both diabetic neuropathy and foot ulceration.