Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleromyxedema

A M Dinneen1, C H Dicken

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

Journal of the American Academy of Dermatology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Scleromyxedema, a rare fibromucinous disorder, has a poor prognosis and is difficult to treat. While alkylating agents may offer short-term benefits for scleromyxedema, long-term use presents significant toxicity.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grover's disease: clinicopathologic review of 72 cases.

Mayo Clinic proceedings·1999
Same author

Simultaneous IgE-mediated urticaria and contact dermatitis from latex.

Allergy·1998
Same author

Porphyria cutanea tarda and human immunodeficiency virus: two cases associated with hepatitis C.

Mayo Clinic proceedings·1998
Same author

Recognizing cutaneous drug eruptions. Reaction patterns provide clues to causes.

Postgraduate medicine·1998
Same author

Trigeminal trophic syndrome.

Mayo Clinic proceedings·1997
Same author

Anetoderma after hepatitis B immunization in two siblings.

Journal of the American Academy of Dermatology·1997
Same journal

Dermatologic conditions associated with HIV among US adults across different racial and ethnic groups: A retrospective cohort study using TriNetX.

Journal of the American Academy of Dermatology·2026
Same journal

Ethical Considerations in Same-Day Surgical Treatment of a High-Risk, Poorly Differentiated Squamous Cell Carcinoma.

Journal of the American Academy of Dermatology·2026
Same journal

The Ethics of the Handshake in Dermatology.

Journal of the American Academy of Dermatology·2026
Same journal

Dermatology images: Hidradenitis suppurativa.

Journal of the American Academy of Dermatology·2026
Same journal

Response to Guo et al., "Response to Huang et al.'s 'Real-world efficacy and safety of tofacitinib on the progression of skin sclerosis in patients with systemic sclerosis: an analysis of national multicenter data from the CRDC.'".

Journal of the American Academy of Dermatology·2026
Same journal

Genomic Predictors of Perineural Invasion in Cutaneous Squamous Cell Carcinoma: Insights from an MD Anderson Cohort.

Journal of the American Academy of Dermatology·2026
See all related articles

Area of Science:

  • Dermatology
  • Oncology
  • Internal Medicine

Background:

  • Scleromyxedema is a rare fibromucinous disorder.
  • Associated with significant morbidity and mortality.
  • Treatment challenges are common.

Purpose of the Study:

  • To investigate the natural history of scleromyxedema.
  • To evaluate the response to alkylating agent therapy.

Main Methods:

  • Clinicopathologic review of 26 scleromyxedema patients.
  • Noted extracutaneous findings.
  • Assessed response to alkylating agents.

Main Results:

  • Extracutaneous manifestations (e.g., gastrointestinal) occurred in 20/26 patients.
  • Abnormal paraproteins (most commonly IgG-lambda) found in 23/26.
  • Melphalan therapy in 17 patients resulted in 10 fatalities.

    • Conclusions:

    • Scleromyxedema carries a poor overall prognosis.
    • Therapy for scleromyxedema is challenging.
    • Alkylating agents show short-term benefit but long-term toxicity.