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[Acid phosphatase (ACP)]

M Igawa¹, H Kishi, T Ishibe

¹Department of Urology, Shimane Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 1, 1995

Summary

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Acid phosphatases, including prostate acid phosphatase (PAP), are enzymes found in human tissues. While PAP is elevated in advanced prostate cancer, prostate-specific antigen (PSA) is a more effective marker for early detection and monitoring.

Area of Science:

Biochemistry
Enzymology
Oncology

Context:

Acid phosphatases are enzymes that hydrolyze orthophosphoric acid esters in an acidic environment.
These enzymes are prevalent across human tissues, with distinct isoenzymes specific to each tissue type.
Prostate acid phosphatase (PAP) is highly concentrated in the human prostate.

Purpose:

To evaluate the utility of serum acid phosphatases, particularly PAP, as tumor markers for prostate cancer.
To compare the diagnostic efficacy of PAP with prostate-specific antigen (PSA) in prostate cancer management.

Summary:

Serum PAP levels increase significantly in prostate cancer patients with bone metastases but lack sensitivity for early-stage detection.
Current diagnostic, staging, and monitoring of prostate cancer show low sensitivity and specificity for serum acid phosphatases and PAP.

Related Experiment Videos

Prostate-specific antigen (PSA) demonstrates superior performance over PAP for prostate cancer diagnosis, screening, and monitoring.

Impact:

Prostate-specific antigen (PSA) is currently the preferred biomarker for prostate cancer diagnosis and monitoring.
Combined testing of PSA and PAP may offer enhanced sensitivity and specificity for prostate cancer detection.
Further research into the role of PAP as an adjunct marker in prostate cancer management is warranted.