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Related Experiment Videos

[N-acetyl-beta-D-glucosaminidase]

N Furuhata1, K Shiba, N Nara

  • 1Department of Clinical Laboratory, Faculty of Medicine, Tokyo Medical and Dental University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1995
PubMed
Summary

Urinary N-acetyl-beta-D-glucosaminidase (NAG) isozymes indicate kidney damage. Measuring these isozymes helps determine the type and severity of renal diseases, particularly those affecting renal tubules.

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Area of Science:

  • Biochemistry
  • Nephrology

Context:

  • N-acetyl-beta-D-glucosaminidase (NAG) is a glycolytic enzyme found in various tissues.
  • Lysosomes in renal proximal tubular cells have high concentrations of NAG.
  • Urinary NAG levels increase upon kidney damage, serving as a biomarker.

Purpose:

  • To investigate the utility of urinary N-acetyl-beta-D-glucosaminidase (NAG) isozymes as indicators of renal damage.
  • To establish reference ranges for NAG isozymes in healthy males and females.

Summary:

  • Electrophoresis separates urinary NAG into three isozymes: pre A, A, and B.
  • Normal male isozyme percentages: pre A (12.3%), A (73.15%), B (14.81%).
  • Normal female isozyme percentages: pre A (12.87%), A (65.47%), B (21.70%).

Impact:

  • Urinary NAG isozyme measurement aids in diagnosing the type and severity of renal diseases.
  • This method is particularly valuable for identifying renal tubular diseases.

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