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Related Concept Videos

Teeth01:15

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Updated: Jun 29, 2025

Oral Health Assessment by Lay Personnel for Older Adults
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Heterogeneous Association of Tooth Loss with Functional Limitations.

Y Matsuyama1, J Aida1, K Kondo2,3

  • 1Department of Oral Health Promotion, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Journal of Dental Research
|March 27, 2024
PubMed
Summary
This summary is machine-generated.

Tooth loss negatively impacts functional capacity in older adults. Machine learning revealed this association varies, with older males, lower socioeconomic status, and poor health being more vulnerable subgroups.

Keywords:
big datadental caredentistryepidemiologymachine learningpublic health

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Area of Science:

  • Gerontology
  • Public Health
  • Biostatistics

Background:

  • Tooth loss is common in older adults and linked to decreased functional capacity.
  • Limited research exists on individual susceptibility to tooth loss effects.

Purpose of the Study:

  • To investigate the heterogeneity of the association between tooth loss and higher-level functional capacity in older Japanese adults.
  • Utilize a machine learning approach to identify vulnerable subgroups.

Main Methods:

  • Prospective cohort study (N=16,553) of Japanese adults aged ≥65 years.
  • Assessed higher-level functional capacity using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC).
  • Employed doubly robust targeted maximum likelihood estimation and causal forest algorithm to analyze associations and heterogeneity.

Main Results:

  • Tooth loss (<20 natural teeth) was significantly associated with lower TMIG-IC scores (population-average effect: -0.14).
  • Causal forest analysis demonstrated heterogeneous associations, with a median conditional average treatment effect (CATE) of -0.13.
  • High-impact subgroups (bottom 10% CATEs) were older, male, had lower socioeconomic status, lacked partners, and reported poorer health.

Conclusions:

  • Significant heterogeneity exists in the impact of tooth loss on functional capacity among older adults.
  • Targeted tooth loss prevention strategies for vulnerable subpopulations (older males, low SES, poor health) are crucial.
  • Addressing tooth loss may effectively reduce its burden on functional capacity in at-risk groups.