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[Selenium deficiency and thyroid hormone metabolism and function]

H Y Wu1, Y M Xia, X S Chen

  • 1Institute of Nutrition and Food Hygiene, Beijing.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|January 1, 1995
PubMed
Summary
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Selenium (Se) deficiency inhibits type I 5'-deiodinase activity, altering thyroid hormone metabolism and potentially contributing to iodine deficiency disorders and Keshan disease.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Nutritional Science

Context:

  • Type I 5 deiodinase is a crucial selenium-dependent enzyme regulating thyroid hormone activation.
  • Selenium deficiency impairs this enzyme's function, leading to altered thyroid hormone levels.
  • Iodine deficiency disorders (IDDs) are a significant public health concern, often exacerbated by other nutritional factors.

Purpose:

  • To investigate the impact of selenium deficiency on type I 5 deiodinase activity and thyroid hormone metabolism.
  • To explore the potential role of selenium deficiency in the pathogenesis of iodine deficiency disorders.
  • To examine the relationship between selenium deficiency, thyroid hormone changes, and Keshan disease.

Summary:

  • Selenium deficiency inhibits type I 5 deiodinase, decreasing T3 and increasing T4 levels.

Related Experiment Videos

  • This impairment accelerates thyroid iodine depletion and worsens iodine deficiency effects.
  • Thyroid hormone metabolic changes due to selenium or iodine deficiency may be linked to Keshan disease development.

    • Impact:

    • Highlights the critical role of selenium in thyroid hormone regulation.
    • Suggests selenium supplementation as a potential strategy to mitigate iodine deficiency consequences.
    • Provides insights into the complex interplay between selenium, iodine, and thyroid health, particularly in conditions like Keshan disease.