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Related Experiment Videos

Renal glomerular fibrosis in two pigs

K Shirota1, T Masaki, H Kitada

  • 1Department of Veterinary Pathology, Azabu University, Kanagawa, Japan.

Veterinary Pathology
|May 1, 1995
PubMed
Summary

Massive collagen fibril deposition was observed in pig kidneys, specifically type-III collagen in the glomeruli. This finding mirrors a newly identified human kidney disease, suggesting a similar etiology.

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Area of Science:

  • Veterinary Pathology
  • Nephrology
  • Biochemistry

Background:

  • Renal glomeruli are vital for kidney filtration.
  • Abnormal extracellular matrix deposition can impair kidney function.
  • Collagenofibrotic glomerulonephropathy is a recently described human glomerular disease.

Purpose of the Study:

  • To characterize massive glomerular collagen fibril deposition in pigs.
  • To investigate the composition and ultrastructure of the deposits.
  • To compare the observed lesions with human collagenofibrotic glomerulonephropathy.

Main Methods:

  • Histopathology with Congo red and Heidenhain's azan staining.
  • Immunohistochemistry to identify collagen types.
  • Electron microscopy to examine fibril ultrastructure.

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Main Results:

  • Two pigs presented with massive homogeneous eosinophilic deposits in renal glomeruli.
  • Deposits were identified as type-III collagen fibrils with ~60 nm periodicity.
  • Glomerular lesions were histologically identical to human collagenofibrotic glomerulonephropathy.

Conclusions:

  • Pigs can develop a condition similar to human collagenofibrotic glomerulonephropathy.
  • The glomerular lesions are characterized by massive type-III collagen deposition.
  • Unusual mesangial cell production of type-III collagen is a potential cause.