Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 28, 2026

Determination of Protein Expression Level in Cultured Cells by Immunocytochemistry on Paraffin-embedded Cell Blocks
09:06

Determination of Protein Expression Level in Cultured Cells by Immunocytochemistry on Paraffin-embedded Cell Blocks

Published on: May 20, 2018

Asbestos contamination in paraffin tissue blocks

R J Lee1, R G Florida, I M Stewart

  • 1RJ Lee Group, Monroeville, Pa, USA.

Archives of Pathology & Laboratory Medicine
|June 1, 1995
PubMed
Summary

Asbestos contamination found in paraffin tissue blocks used for mesothelioma diagnosis raises concerns. This discovery necessitates reevaluation of asbestos exposure assessments and related studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidental splenic artery aneurysms: systematic literature review and single-centre study.

Clinical radiology·2026
Same author

Growth patterns of true renal artery aneurysms in the current published literature.

Clinical radiology·2025
Same author

Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Apparatus for skidding sensitivity testing of energetic materials.

The Review of scientific instruments·2021
Same author

Erratum to 'Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome': [ESMO Open Volume 6, Issue 1, February 2021, 100005].

ESMO open·2021
Same author

Longitudinal characterisation of haematological and biochemical parameters in cancer patients prior to and during COVID-19 reveals features associated with outcome.

ESMO open·2021

Area of Science:

  • Environmental Health
  • Pathology
  • Occupational Medicine

Background:

  • Mesothelioma diagnoses often rely on electron microscopic analysis of asbestos in paraffin-embedded tissue.
  • Asbestos exposure is a known cause of mesothelioma, a rare cancer.

Purpose of the Study:

  • To investigate the prevalence of asbestos contamination in paraffin tissue blocks.
  • To assess the implications of this contamination on the validity of asbestos exposure diagnoses.

Main Methods:

  • Analysis of paraffin blocks from hospitals in six major cities.
  • Electron microscopic examination of tissue samples.

Main Results:

  • Measurable concentrations of asbestos were detected in paraffin tissue blocks.
  • Asbestos contamination was observed in samples from multiple locations.

Conclusions:

  • The presence of asbestos in paraffin blocks challenges the reliability of asbestos detection for mesothelioma diagnosis.
  • Studies on asbestos migration and exposure validation require critical reevaluation, especially if control blanks were not used.

More Related Videos

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing
11:00

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Published on: November 29, 2018

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Related Experiment Videos

Last Updated: Jul 28, 2026

Determination of Protein Expression Level in Cultured Cells by Immunocytochemistry on Paraffin-embedded Cell Blocks
09:06

Determination of Protein Expression Level in Cultured Cells by Immunocytochemistry on Paraffin-embedded Cell Blocks

Published on: May 20, 2018

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing
11:00

Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing

Published on: November 29, 2018

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022