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Related Experiment Videos

Reduction in bowel program duration with polyethylene glycol based bisacodyl suppositories

S A Stiens1

  • 1Veterans Affairs Medical Center SCI Service, Seattle, WA, USA.

Archives of Physical Medicine and Rehabilitation
|July 1, 1995
PubMed
Summary

Polyethylene glycol based bisacodyl suppositories (PGB) significantly reduced bowel program (BP) time in spinal cord injury (SCI) patients compared to hydrogenated vegetable oil based bisacodyl suppositories (HVB). PGB offers a faster, more effective defecation experience for neurogenic bowel management.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Rehabilitation Medicine

Background:

  • Neurogenic bowel dysfunction is a common complication of spinal cord injury (SCI).
  • Bowel programs (BPs) utilizing stimulant suppositories are essential for managing defecation in SCI patients.
  • Comparing different suppository formulations is crucial for optimizing BP effectiveness.

Observation:

  • This study compared hydrogenated vegetable oil based bisacodyl (HVB) suppositories with polyethylene glycol based bisacodyl suppositories (PGB) in a randomized, single-subject design.
  • Participants had chronic T2 complete spinal cord injury (SCI) and were managed in an outpatient setting.
  • Key BP intervals, including time to flatus and defecation period, were meticulously recorded.

Findings:

  • Polyethylene glycol based bisacodyl suppositories (PGB) demonstrated a significantly shorter Time to Flatus (10 minutes) compared to HVB (37 minutes) (p < .0001).

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  • The Defecation Period was also significantly shorter with PGB (21 minutes) versus HVB (31 minutes) (p = .0043).
  • No significant difference was observed in the Flatus to Stool Flow interval between the two suppository types (p = .9578).

    • Implications:

    • Polyethylene glycol based bisacodyl suppositories represent a more efficient option for initiating bowel programs in individuals with SCI.
    • Optimizing BP intervals can lead to improved patient outcomes and quality of life.
    • Further research may explore long-term efficacy and patient-reported satisfaction with PGB formulations.