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Severe accidental dapsone overdose

M D McGoldrick1, G R Bailie

  • 1Albany Medical College, NY, USA.

The American Journal of Emergency Medicine
|July 1, 1995
PubMed
Summary
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Acute dapsone poisoning is rare but increasing due to new uses. Accidental dapsone intoxication caused severe cyanosis and elevated methemoglobin levels in a patient.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Dapsone (4,4-diaminodiphenylsulfone) is increasingly prescribed for conditions beyond leprosy, including acne vulgaris, psoriasis, and Pneumocystis carinii pneumonia in AIDS patients.
  • Acute dapsone poisoning is uncommon in the United States, with no reported cases in 1992.

Observation:

  • This report details a case of accidental dapsone intoxication.
  • The patient presented with severe cyanosis.

Findings:

  • The dapsone intoxication resulted in a modest elevation in methemoglobin concentration.
  • Cyanosis was a prominent clinical sign of toxicity.

Implications:

  • Clinicians must be aware of dapsone's potential toxicities with its expanding therapeutic applications.

Related Experiment Videos

  • Recognition of cyanosis and methemoglobinemia is crucial for managing dapsone overdose.
  • This case highlights the importance of monitoring patients for adverse effects of dapsone.