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Open study of clobazam in refractory epilepsy
Pediatric Neurology
|November 1, 1993
Summary
Clobazam, a 1,5-benzodiazepine, effectively controlled seizures in children with intractable epilepsy. This antiepileptic drug demonstrated less neurotoxicity compared to 1,4-benzodiazepines, improving neurologic function in many patients.
Area of Science:
- Neuroscience
- Pharmacology
- Pediatric Neurology
Background:
- Clobazam is a 1,5-benzodiazepine with broad antiepileptic activity.
- It is considered to have fewer neurotoxic effects than 1,4-benzodiazepines like nitrazepam and clonazepam.
Purpose of the Study:
- To prospectively evaluate the efficacy and safety of clobazam in children with intractable seizures.
- To assess the impact of clobazam on seizure control and neurologic behavior.
Main Methods:
- Prospective study involving 115 children (average age 8.4 years) with intractable seizures.
- Evaluation of seizure frequency reduction and changes in neurologic function parameters.
- Analysis of tolerance development and comparison with 1,4-benzodiazepine use.
Main Results:
- 16% of children became seizure-free, and 31% experienced over 90% seizure reduction.
- 38% developed tolerance to clobazam's antiepileptic effects, with some responding to dose increases.
- 72% showed improved neurologic function, particularly those switching from 1,4-benzodiazepines, with better attention, alertness, balance, mood, and reduced drooling.
Conclusions:
- Clobazam is effective for treating diverse epilepsies and seizure types in children.
- Clobazam appears to be associated with less neurotoxicity than 1,4-benzodiazepines, supporting its clinical use.