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Suspected ciprofloxacin-induced hepatotoxicity
J P Villeneuve1, C Davies, J Côté
1Department of Medicine, Hôpital Saint-Luc, Montréal, Canada.
The Annals of Pharmacotherapy
|March 1, 1995
Summary
This case report details severe hepatitis likely caused by ciprofloxacin, a fluoroquinolone antibiotic. Healthcare providers should monitor for this adverse drug reaction during ciprofloxacin therapy.
Area of Science:
- Hepatology
- Pharmacology
- Clinical Toxicology
Background:
- Fluoroquinolone antibiotics, including ciprofloxacin, are widely prescribed.
- Adverse drug reactions can significantly impact patient safety and treatment outcomes.
Observation:
- A 44-year-old woman presented with severe hepatitis 3 weeks after a 7-day course of oral ciprofloxacin.
- Liver biopsy revealed severe hepatic necrosis, with other causes of liver injury excluded.
- Complete recovery of liver function was observed 4 months post-jaundice onset.
Findings:
- The temporal relationship between ciprofloxacin use and the onset of severe hepatitis strongly suggests a causal link.
- Exclusion of alternative etiologies supports drug-induced liver injury.
- Previous unpublished reports indicate a potential for ciprofloxacin-induced hepatotoxicity.
Implications:
- Ciprofloxacin may cause severe hepatic injury, necessitating clinical awareness.
- Healthcare providers should consider ciprofloxacin as a potential cause of hepatitis in patients presenting with liver dysfunction.
- Vigilance for this adverse drug reaction is crucial for patient safety during fluoroquinolone therapy.