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Atrial myxoma with multiple myeloma
Archives of Internal Medicine
|January 1, 1979
Summary
A left atrial myxoma triggered an immune response, leading to the development of IgG multiple myeloma in a patient. This case highlights the potential for tumors to cause malignant transformation of immune cells.
Area of Science:
- Immunology
- Oncology
- Neurology
Background:
- Atrial myxomas can present with diverse systemic symptoms.
- Understanding the link between benign tumors and hematologic malignancies is crucial.
Observation:
- A seven-year observation of a male patient with neurologic symptoms.
- Early findings included elevated serum gamma-globulin and normal bone marrow.
- Progressive increase in gamma-globulin and bone marrow infiltration by plasma cells observed.
Findings:
- Surgical removal of a left atrial myxoma coincided with diagnosis.
- Monoclonal increase of K light chain IgG identified.
- Bone marrow showed 60% infiltration by immature plasma cells.
Implications:
- Continuous immunologic stimulation by atrial tumor products may induce malignant transformation.
- This case suggests a potential pathway from benign tumor to IgG multiple myeloma.
- Highlights the importance of investigating systemic symptoms in patients with atrial myxoma.