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Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients
M S Bianchi1, N O Bianchi, G Bailliet
1Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina.
Cytogenetics and Cell Genetics
|January 1, 1995
Abstract:
We have characterized the mtDNA in normal and breast cancer tissues from seven patients. Both types of tissue showed point mutation heteroplasmies and extensive deletions of the mtDNA. The analysis of these polymorphisms allowed us to infer the mtDNA composition of the breast cell that underwent malignant transformation.