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Isotopic response

R Wolf¹, S Brenner, V Ruocco

¹Department of Dermatology, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel.

International Journal of Dermatology

|May 1, 1995

Summary

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The isotopic response is a new skin disorder appearing at the site of a previous, healed one. This phenomenon, observed in 58 cases, involves various initial and subsequent skin conditions, aiding dermatologic classification.

Area of Science:

Dermatology
Pathology

Background:

The isotopic response, a rare dermatologic phenomenon, describes the development of a new skin condition at the site of a prior, unrelated, healed skin disease.
First described in 1955 and precisely defined by Wolf et al. in 1985, 58 cases have been documented.

Observation:

The initial condition in most documented cases was herpes zoster, followed by herpes simplex, varicella, or thrombophlebitis.
Subsequent skin conditions at the original site most frequently included carcinoma (especially breast carcinoma) or granuloma annulare.

Findings:

A total of 58 cases of isotopic response were analyzed, with diverse initial and secondary skin diseases identified.
Common initial diseases were herpes zoster and herpes simplex, while common secondary diseases included various carcinomas and granuloma annulare.

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The location and time interval between the initial and subsequent diseases showed no specific predilections.

Implications:

The term "isotopic response" is proposed for inclusion in dermatologic glossaries to standardize terminology.
Establishing a unified term facilitates case collection, retrieval, and research into the underlying mechanisms of this phenomenon.