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Updated: Sep 30, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Prevalence of deep venous thrombosis among patients in medical intensive care
D R Hirsch1, E P Ingenito, S Z Goldhaber
1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
OBJECTIVE--To determine the frequency of deep venous thrombosis (DVT) in medical intensive care unit (MICU) patients. DESIGN--Prospective ultrasound case series. SETTING--An MICU in a large tertiary care hospital in Boston, Mass. SUBJECTS--Patients older than 18 years of age admitted to the MICU with an anticipated stay of more than 48 hours. MAIN OUTCOME MEASURE--Deep venous thrombosis as detected by ultrasonography with color Doppler imaging performed twice weekly in the MICU and once within 1 week of discharge from the MICU. RESULTS--Deep venous thrombosis was detected in 33% (95% confidence interval, 24% to 43%) of 100 eligible patients during the 8-month study period. Forty-eight percent (16/33) were proximal lower extremity DVT, and 15% (5/33) were upper extremity DVT associated with central venous catheters, with one patient having both upper and proximal lower extremity DVT. Ultrasound examination results led to inferior vena cava filter placement in three patients, initiation of full-dose anticoagulation in four patients, initiation or continuation of low-dose subcutaneous heparin in 10 patients, follow-up ultrasound studies in three patients, central line removal in one patient, and no intervention in 10 patients due to active bleeding, prior filter, or heparin-induced thrombocytopenia. Two patients remained anticoagulated for other reasons. In this series, there was no difference in age, gender, body mass index, diagnosis of cancer, recent surgery, duration of hospitalization prior to DVT detection, and DVT prophylaxis between patients with DVT and those without. CONCLUSIONS--An unexpectedly high rate of DVT was detected by ultrasound in these MICU patients despite prophylaxis in 61%. Traditionally recognized DVT risk factors failed to identify patients who developed DVT. Routine ultrasound surveillance or more intensive prophylaxis regimens may be warranted in this patient population if these DVT rates are confirmed in other settings.
Insights
Deep venous thrombosis (DVT) occurred in 33% of medical intensive care unit (MICU) patients, despite prophylaxis. Traditional risk factors did not predict DVT development in this high-risk population.
Area of Science:
- Critical Care Medicine
- Vascular Medicine
- Diagnostic Imaging
Background:
- Deep venous thrombosis (DVT) is a significant concern in critically ill patients.
- Identifying DVT risk factors and effective prevention strategies in the medical intensive care unit (MICU) is crucial.
Purpose of the Study:
- To determine the incidence of DVT in patients admitted to a medical intensive care unit (MICU).
- To evaluate the effectiveness of traditional DVT risk factors in predicting DVT in MICU patients.
Main Methods:
- Prospective ultrasound case series involving 100 eligible MICU patients.
- Ultrasonography with color Doppler imaging performed twice weekly and before discharge.
- Inclusion criteria: patients >18 years old with anticipated MICU stay >48 hours.
Main Results:
- DVT was detected in 33% of patients, with proximal lower extremity DVT in 48% and upper extremity DVT in 15%.
- No significant differences in traditional risk factors (age, BMI, cancer, surgery) were found between patients with and without DVT.
- Despite 61% receiving DVT prophylaxis, the DVT rate was unexpectedly high.
Conclusions:
- The incidence of DVT in MICU patients is higher than previously recognized.
- Traditional DVT risk factors are insufficient for identifying high-risk patients in the MICU.
- Routine ultrasound surveillance or enhanced prophylaxis may be necessary for MICU patients.
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