[Stimulation of erythropoiesis in hemorrhage during pregnancy using microvesicles from erythrocyte plasmolemma]

Autologous microvesicles of erythrocyte plasmalemma were obtained by means of ultrasound treatment of erythrocyte suspension. These microvesicles were intravenously (i.v.) injected to pregnant rabbits with artificial bleeding at the 21st day of gestation. Three i.v. injections of microvesicles with 1-3 day interval at the amount equal to 1% of the weight of the circulating erythrocyte plasmalemma increased almost to the control level the number of erythrocytes and hemoglobulin by the 8th day after the bleeding while these indices were much lower in untreated animals.