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Theophylline pharmacokinetics in Thai children
P Vichyanond1, N Aranyanark, N Visitsuntorn
1Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Asian Pacific Journal of Allergy and Immunology
|December 1, 1994
Summary
This study found that the suggested oral aminophylline dosage for Thai children with asthma led to toxic serum theophylline concentrations in some patients, indicating a need for dosage adjustment. Pharmacokinetic parameters showed significant interpatient variability.
Area of Science:
- Pharmacology
- Pediatric Asthma Management
- Clinical Pharmacokinetics
Background:
- Theophylline is a bronchodilator used for asthma management.
- Established dosing regimens require validation in specific pediatric populations.
- Thai children may exhibit unique pharmacokinetic profiles.
Purpose of the Study:
- To validate a proposed oral aminophylline dosing regimen in Thai children with asthma.
- To assess theophylline pharmacokinetics in this population.
- To identify potential toxicity associated with the regimen.
Main Methods:
- A 36-hour multiple-dose oral theophylline pharmacokinetic study was conducted.
- 13 asthmatic Thai children received aminophylline (5 mg/kg every 8 hours).
- Serum theophylline concentrations were measured, and pharmacokinetic parameters were calculated.
Main Results:
- Significant interpatient variability in serum theophylline concentrations was observed.
- Five patients experienced peak concentrations in the toxic range (> 20 µg/ml).
- Mean fluctuation in serum theophylline concentrations was 535.6%.
Conclusions:
- The suggested oral aminophylline dosing regimen is potentially toxic for Thai children.
- Dosage adjustments may be necessary to ensure therapeutic efficacy and safety.
- Further pharmacokinetic studies, including intravenous administration, are warranted.