Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroendocrine-immune system interactions and autoimmunity

R L Wilder1

  • 1Inflammatory Joint Diseases Section, National Institutes of Health, Bethesda, Maryland 20892, USA.

Annual Review of Immunology
|January 1, 1995
PubMed
Summary

The neuroendocrine-immune system coordinates stress responses, but dysregulation contributes to autoimmune diseases in animals and humans. Understanding this interaction is key to addressing immune system disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases.

Annals of the rheumatic diseases·2002
Same author

Genetic factors regulating experimental arthritis in mice and rats.

Current directions in autoimmunity·2002
Same author

Genetic factors involved in central nervous system/immune interactions.

Advances in experimental medicine and biology·2001
Same author

IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times.

The Journal of clinical endocrinology and metabolism·2001
Same author

Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains.

Immunogenetics·2001
Same author

Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains.

Genes and immunity·2001

Area of Science:

  • Neuroimmunology
  • Endocrinology
  • Stress Physiology

Background:

  • The neuroendocrine-immune system forms an integrated adaptive response to stress.
  • This response is modulated by intrinsic factors (age, gender, genetics) and extrinsic challenges.
  • Dysfunctional communication within this system is implicated in autoimmune diseases.

Purpose of the Study:

  • To review the integrated neuroendocrine-immune adaptive response to stress.
  • To highlight the role of neuroendocrine-immune dysfunction in autoimmune disease pathogenesis.
  • To discuss key regulatory pathways and molecules involved in the stress response.

Main Methods:

  • Review of experimental evidence supporting the integrated neuroendocrine-immune response.
  • Analysis of factors influencing the stress response quality and intensity.
  • Discussion of animal models and human diseases linked to neuroendocrine-immune dysfunction.

Main Results:

  • The stress response varies significantly based on individual and environmental factors.
  • Neuroendocrine-immune system dysfunction is a contributing factor in various animal models of autoimmune disease.
  • This dysfunction is also implicated in human autoimmune conditions like rheumatoid arthritis and lupus.

Conclusions:

  • Integrated neuroendocrine-immune pathways are crucial for adaptive stress responses.
  • Disruptions in these pathways are central to the development of autoimmune diseases.
  • Further research into these interactions is vital for understanding and treating immune-mediated disorders.

Related Experiment Videos