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Related Experiment Videos

Positive selection of thymocytes

S C Jameson1, K A Hogquist, M J Bevan

  • 1University of Washington, Howard Hughes Medical Institute, Seattle 98195, USA.

Annual Review of Immunology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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T cell differentiation requires interaction with self-MHC molecules. Recent findings suggest low-avidity binding of peptide/MHC ligands to T cell receptors (TCRs) distinguishes positive from negative selection, guiding T cell maturation.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • T cell differentiation in the thymus involves positive selection (survival and maturation) and negative selection (elimination of autoreactive cells).
  • Both processes rely on T cell receptor (TCR) interactions with self-major histocompatibility complex (MHC) molecules, presenting shared features like MHC-allele specificity and peptide recognition.

Purpose of the Study:

  • To review recent advances in understanding the discrimination between positive and negative selection pathways in T cell development.
  • To explore the molecular basis for distinguishing TCR ligands that induce positive versus negative selection.

Main Methods:

  • Review of recent immunological and cell biology research.
  • Analysis of systems for manipulating components involved in positive selection.

Related Experiment Videos

  • Discussion of emerging data on TCR-ligand interactions.

    • Main Results:

    • Recent work suggests that peptide/MHC ligands inducing positive selection may bind with low avidity to the TCR.
    • This low-avidity binding is proposed as a key discriminator between positive and negative selection pathways.

    Conclusions:

    • Understanding the basis for discrimination between positive and negative selection is crucial for T cell development.
    • Low TCR avidity for peptide/MHC ligands may be a critical factor in promoting T cell survival and differentiation during positive selection.