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IgA and mucosal defense

M E Lamm1, J G Nedrud, C S Kaetzel

  • 1Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4907, USA.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 1, 1995
PubMed
Summary

Immunoglobulin A (IgA) antibodies offer more than just a mucosal barrier. New research suggests IgA can neutralize intracellular pathogens and aid in antigen excretion, enhancing infection recovery.

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Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • The established role of Immunoglobulin A (IgA) in mucosal immunity involves forming a barrier against exogenous pathogens.
  • Recent findings indicate potential novel functions for IgA beyond passive immune exclusion.

Purpose of the Study:

  • To explore the emerging evidence for additional roles of IgA in mucosal defense mechanisms.
  • To investigate IgA's capacity to neutralize intracellular pathogens and facilitate antigen clearance.

Main Methods:

  • In vitro and in vivo studies were conducted to observe IgA functions.
  • Analysis of IgA antibody interactions within epithelial cells and the lamina propria.

Main Results:

  • IgA antibodies may neutralize intracellular pathogens, such as viruses, during their transport through epithelial cells.
  • IgA can complex with antigens in the lamina propria and facilitate their excretion via mucosal epithelium.

Conclusions:

  • IgA possesses multifaceted roles in mucosal defense, extending beyond barrier function.
  • These newly identified functions of IgA may significantly contribute to host recovery from infections.

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