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Repeated diazepam administration influences 5-HT1A receptor binding in the rat brain

S Rump¹, I Jakowicz

¹Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology

|March 1, 1995

Abstract:

Repeated administration of diazepam for 14 days (5 mg/kg daily) resulted in a significant increase of 5-HT1A receptor density in the midbrain of the rat. Bmax values were increased from 239.6 to 684.9 fmol/mg. The affinity constants (KD) were also increased, from 0.97 to 3.01 nM/l.

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