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Food allergens transformed into tolerogens

Y Borel1, R Fritsché, H Borel

  • 1Nestec Ltd. Research Centre, Lausanne, Switzerland.

International Archives of Allergy and Immunology
|May 1, 1995
PubMed
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Modifying allergen presentation by linking ovalbumin to rat IgG can prevent allergic responses. This protein-IgG conjugate specifically down-regulates T and B cell immunity, offering a novel allergy prevention strategy.

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Antigen presentation is critical for determining immunologic outcomes.
  • Modifying allergen presentation can prevent allergic responses.

Purpose of the Study:

  • To investigate if covalent linkage of ovalbumin to rat IgG can down-regulate immune responses to this food allergen.
  • To determine if this strategy can prevent allergic reactions.

Main Methods:

  • Covalent linkage of ovalbumin to rat IgG to create a protein-IgG conjugate.
  • Administration of the conjugate to hosts to assess immune response modulation.

Main Results:

  • The protein-IgG conjugate effectively down-regulated the immune response to ovalbumin.
  • The suppression was allergen-specific.

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  • Both T cell and B cell immune responses were affected.

    • Conclusions:

    • Linking allergens to isologous IgG is a potential strategy for allergy prevention.
    • This method offers allergen-specific suppression of immune responses.