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Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockade
A A Nasher1, A A Qirbi, M A Ghafoor
1Department of Surgery, Faculty of Medicine, University of Sana'a, Republic of Yemen.
Objective:
To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
Subjects And Methods:
The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo.
Results:
Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin.
Conclusions:
The urinary side-effects of khat chewing are probably mediated through stimulation of alpha 1-adrenergic receptors.