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Premenopausal bleeding associated with hyperprolactinaemia

E Ratchev1, S Dokumov

  • 1Department of Obstetrics and Gynaecology, University Hospital Maitchin Dom, Sofia, Bulgaria.

Maturitas
|April 1, 1995
PubMed
Summary
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Climacteric women experiencing premenopausal bleeding showed elevated serum prolactin levels compared to healthy women. Age also influenced prolactin levels, suggesting a link to ovarian function changes.

Area of Science:

  • Reproductive Endocrinology
  • Gynecology

Background:

  • Premenopausal bleeding is common in climacteric women.
  • Elevated prolactin levels (hyperprolactinemia) can affect reproductive function.

Purpose of the Study:

  • To investigate serum prolactin levels in climacteric women with premenopausal bleeding.
  • To compare these levels with healthy women and hyperprolactinemic patients.

Main Methods:

  • Assessed 54 climacteric women for premenopausal bleeding.
  • Measured serum prolactin levels.
  • Compared results with 35 healthy women and 28 hyperprolactinemic patients.
  • Performed skull X-rays and endometrial curettage.

Main Results:

  • Mean serum prolactin was 23.04 ng/ml in climacteric women, significantly higher than healthy controls (P < 0.001).

Related Experiment Videos

  • Hyperprolactinemic patients had a mean of 34.43 mg/ml.
  • Anovulatory bleeding was predominant.
  • Age positively correlated with serum prolactin levels (r = 0.406).
  • No sella turcica abnormalities were found.

    • Conclusions:

    • Serum prolactin levels are significantly increased in climacteric women with premenopausal bleeding.
    • Elevated prolactin may be associated with anovulatory bleeding and age-related ovarian changes.
    • The exact role of hyperprolactinemia in climacteric ovarian dysfunction requires further investigation.