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Related Experiment Videos

Apraxia during Wada testing

A L Foundas1, R Henchey, R L Gilmore

  • 1Department of Psychiatry and Neurology, Tulane University School of Medicine, New Orleans, LA 70112-2632, USA.

Neurology
|July 1, 1995
PubMed
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In right-handers, both speech and skilled motor functions (praxis) are typically left-hemisphere dominant. However, praxis shows more bilateral representation than language, suggesting distinct hemispheric roles.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Apraxia, the inability to perform learned skilled movements, is often associated with left-hemisphere lesions in right-handers, similar to aphasia.
  • Dissociation between apraxia and aphasia suggests differing hemispheric lateralization or network distribution for these functions.
  • Existing hypotheses propose either right-hemisphere involvement in praxis or a more extensive left-hemisphere network for language compared to praxis.

Purpose of the Study:

  • To investigate the hemispheric lateralization of praxis in right-handers using Wada testing.
  • To compare the lateralization patterns of praxis with those of language.
  • To explore potential differential roles of the cerebral hemispheres in executing skilled movements.

Main Methods:

Related Experiment Videos

  • Selective hemispheric anesthesia (Wada testing) was performed on a group of right-handed subjects.
  • Language lateralization was assessed for all participants.
  • Praxis (skilled motor function) was evaluated, and error types were analyzed to infer hemispheric contributions.

Main Results:

  • All nine subjects demonstrated left-hemisphere lateralization for language.
  • Seven out of nine subjects showed left-hemisphere lateralization for praxis.
  • Two subjects exhibited bilateral representation of praxis, indicating a more distributed network compared to language.

Conclusions:

  • While both language and praxis are predominantly left-hemisphere functions in most right-handers, praxis demonstrates greater bilateral representation.
  • These findings suggest that the neural networks underlying praxis are more distributed across hemispheres than those for speech-language functions.
  • Analysis of praxis errors indicates distinct hemispheric contributions to skilled motor control.