Fibrin sealant in interventional radiology: a preliminary evaluation

Area of Science:

• Surgical innovation
• Biomaterials science
• Gastroenterology

Background:

• Abdominal fistulas and sinuses present significant clinical challenges.
• Interventional biliary procedures require effective methods for sealing tracts.
• Fibrin sealants offer potential for tissue approximation and sealing.

Purpose of the Study:

• To evaluate the efficacy of Tisseel, a fibrin sealant, in sealing abdominal fistulas/sinuses.
• To assess Tisseel's effectiveness in interventional biliary procedures.
• To determine the permanence of tract sealing using Tisseel.

Main Methods:

• Tisseel, a two-component fibrin sealant, was administered using a double-lumen catheter.
• The sealant was applied to abdominal fistulas and sinuses in 13 patients.
• The sealant was used in 11 patients undergoing interventional biliary procedures.

Main Results:

• Permanent sealing was achieved in seven of the 13 patients with abdominal fistulas and sinuses.
• Tisseel successfully sealed all 11 tracts in interventional biliary procedures.
• Fibrin gel formation at the point of contact facilitated tract sealing.

Conclusions:

• Tisseel demonstrates significant potential for sealing abdominal fistulas and sinuses.
• Tisseel is highly effective for sealing tracts in interventional biliary procedures.
• The fibrin sealant offers a promising solution for challenging surgical sealing applications.