Standard reference materials and data quality assurance: the lesson from the analysis of trace elements

Area of Science:

• Biomedical analysis
• Analytical chemistry
• Clinical diagnostics

Background:

• Accurate and precise analytical data on trace element and compound concentrations are crucial for bioclinical studies.
• Standard reference materials (SRMs) with known analyte concentrations are essential for reliable measurements.
• The availability and proper use of SRMs directly impact the quality of bioclinical research.

Purpose of the Study:

• To review the current status of standard reference materials for trace element analysis in biological specimens.
• To outline the critical requirements for the preparation of these materials.
• To discuss the essential considerations for the application of these materials in bioclinical settings.

Main Methods:

• Literature review of existing standard reference materials for trace element analysis.
• Analysis of requirements for material preparation.
• Discussion of application protocols and challenges.

Main Results:

• Identified key challenges in the availability and characterization of SRMs for biological matrices.
• Detailed essential criteria for the preparation of homogeneous and stable SRMs.
• Highlighted best practices for the application of SRMs to ensure data accuracy and precision.

Conclusions:

• Standard reference materials are indispensable for accurate trace element analysis in biological specimens.
• Adherence to stringent preparation and application guidelines is necessary for effective use of SRMs.
• Further development and availability of SRMs will enhance the reliability of bioclinical data.