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Selective decrease of the suppressor-inducer (CD4+CD45RA+) T lymphocytes in workers exposed to benzidine and

H L ng1, S Araki, T Tanigawa

  • 1Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.

Archives of Environmental Health
|May 1, 1995
PubMed
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Occupational exposure to aromatic amines significantly reduces CD4+CD45RA+ (suppressor-inducer) T cells in dyestuff workers. This finding highlights the impact of aromatic amines on immune cell populations, particularly within the high-exposure group.

Area of Science:

  • Immunology
  • Occupational Health
  • Toxicology

Background:

  • Previous research indicated decreased CD4+ T lymphocytes in workers exposed to aromatic amines like benzidine and beta-naphthylamine.
  • Aromatic amines are industrial chemicals used in dyestuff production, posing potential health risks to exposed workers.

Purpose of the Study:

  • To investigate the effects of occupational exposure to aromatic amines on CD4+ T lymphocyte subpopulations (CD4+CD45RA+ and CD4+CD29+ cells), total CD4+ T lymphocytes, and CD8+ T lymphocytes.
  • To compare immune cell profiles between high-exposure aromatic amine production workers, low-exposure dyestuff handlers, and a control group.

Main Methods:

  • Flow cytometry was used to measure absolute and relative numbers of T lymphocyte subpopulations.
  • Seventy-eight male dyestuff workers (40 high-exposure, 38 low-exposure) and 30 healthy male volunteers (control) participated.

Related Experiment Videos

  • Analysis of covariance was employed to control for age effects.

    • Main Results:

    • The high-exposure group showed significantly lower absolute and relative numbers of CD4+CD45RA+ (suppressor-inducer) T lymphocytes compared to the control group.
    • Relative numbers of total CD4+ T lymphocytes were also significantly lower in the high-exposure group versus controls.
    • No significant differences were observed in CD4+CD29+ or CD8+ T lymphocytes between groups.

    Conclusions:

    • CD4+CD45RA+ T lymphocytes are a primary target for the adverse effects of aromatic amine exposure.
    • Occupational exposure to aromatic amines can lead to significant alterations in T lymphocyte subpopulations, impacting immune function.