Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variability in sib pair genetic identity

B K Suarez, T Reich, P M Fishman

    Human Heredity
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Full sibling genetic identity shows consistent variability, with a standard deviation around 0.056 for the autosomal genome identical by descent (IBD). This variability remains stable even in larger families, unaffected by complex sibling relationships.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Plutonium mobility and reactivity in a heterogeneous clay rock barrier accented by synchrotron-based microscopic chemical imaging.

    Scientific reports·2024
    Same author

    Do perchlorate and triflate anions bind to the uranyl cation in an acidic aqueous medium? A combined EXAFS and quantum mechanical investigation.

    Chemphyschem : a European journal of chemical physics and physical chemistry·2013
    Same author

    Meta-analysis of 32 genome-wide linkage studies of schizophrenia.

    Molecular psychiatry·2009
    Same author

    Co-occurring risk factors for alcohol dependence and habitual smoking.

    Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism·2005
    Same author

    Evidence of association between bipolar disorder and Citron on chromosome 12q24.

    Molecular psychiatry·2005
    Same author

    A sex-adjusted and age-adjusted genome screen for nested alcohol dependence diagnoses.

    Psychiatric genetics·2005
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Area of Science:

    • Genetics
    • Computational Biology
    • Population Genetics

    Background:

    • Meiotic recombination is a fundamental process in sexual reproduction, generating genetic diversity.
    • Understanding the variability in genetic identity among siblings is crucial for genetic studies, including association studies and pedigree analysis.
    • Previous estimates of sibling genetic identity variability have often relied on theoretical models or limited empirical data.

    Purpose of the Study:

    • To estimate the variability in genetic identity among full siblings using a realistic model of meiotic crossing over.
    • To quantify the standard deviation of the percentage of the autosomal genome identical by descent (IBD) in full sib pairs.
    • To investigate whether sibship size influences the variability of genetic identity within families.

    Main Methods:

    Related Experiment Videos

    • A realistic computational model simulating meiotic crossing over was employed.
    • 200 independent pairs of full siblings were simulated to estimate genetic identity.
    • Simulations were extended to sibships larger than size two to assess the impact of family structure.

    Main Results:

    • The standard deviation for the percentage of the autosomal genome identical by descent (IBD) was estimated to be approximately 0.056.
    • Simulations involving larger sibships (size > 2) showed average within-sibship standard deviations ranging from 0.054 to 0.056.
    • These results indicate that sib pair variability in genetic identity is largely insensitive to the nonindependence structures present in larger sibships.

    Conclusions:

    • The variability in genetic identity among full siblings is consistently estimated around 0.056 for autosomal regions.
    • Family structure in larger sibships does not significantly alter the observed variability in genetic identity between sibling pairs.
    • These findings provide a robust quantitative estimate for sibling genetic identity variability, valuable for genetic research methodologies.