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A paradigm 1994: the allograft response
1Department of Medicine, Harvard Medical School, Boston, Mass, USA.
This review presents our concepts regarding the mechanisms of rejection and the pathway leading to graft tolerance. Allograft rejection is a T-cell-dependent process. Accordingly, we discuss the current understanding of T cell activation and cytokine production and then apply these concepts to the mechanisms that cause rejection and tolerance. We describe the ability of renal epithelial cells to either induce T cell activation or anergy. Finally, we review potential mechanisms responsible for the maintenance of tolerance.
This review presents our concepts regarding the mechanisms of rejection and the pathway leading to graft tolerance. Allograft rejection is a T-cell-dependent process. Accordingly, we discuss the current understanding of T cell activation and cytokine production and then apply these concepts to the mechanisms that cause rejection and tolerance. We describe the ability of renal epithelial cells to either induce T cell activation or anergy. Finally, we review potential mechanisms responsible for the maintenance of tolerance.