Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic dysfunction in Parkinson's disease, tested with a computerized method using a Finapres device

P M Netten1, K de Vos, M W Horstink

  • 1Department of Internal Medicine, The Netherlands.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlations between peripheral blood Coxiella burnetii DNA load, interleukin-6 levels, and C-reactive protein levels in patients with acute Q fever.

Clinical and vaccine immunology : CVI·2014
Same author

FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome.

Neurology·2008
Same author

Rare localisation of air.

The Netherlands journal of medicine·2007
Same author

ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease.

Neurology·2007
Same author

Status epilepticus caused by a myxoedema coma.

The Netherlands journal of medicine·2006
Same author

Prevalence and clinical characteristics of insulin-treated, anti-GAD-positive, type 2 diabetic subjects in an outpatient clinical department of a Dutch teaching hospital.

The Netherlands journal of medicine·2006

Cardiovascular autonomic dysfunction was detected in 23% of Parkinson's disease patients using an automated reflex test program. This screening method identified dysfunction not present in healthy controls.

Area of Science:

  • Neurology
  • Cardiology
  • Autonomic Nervous System Function

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder that can affect the autonomic nervous system.
  • Cardiovascular autonomic dysfunction is a common non-motor symptom in PD, impacting patient quality of life.
  • Early detection and management of autonomic dysfunction are crucial for PD patients.

Purpose of the Study:

  • To develop and validate an automated program for assessing cardiovascular autonomic dysfunction.
  • To screen for autonomic dysfunction in ambulant Parkinson's disease patients using non-invasive cardiovascular reflex tests.
  • To compare autonomic function between PD patients and age-matched healthy controls.

Main Methods:

  • An automated program utilizing a Finapres device and personal computer was developed.

Related Experiment Videos

  • A battery of five cardiovascular reflex tests was administered to 23 PD patients and 23 controls.
  • Data analysis focused on heart rate and blood pressure responses to various stimuli.

    • Main Results:

    • Abnormal heart rate responses were observed in PD patients during forced breathing (26.1%), standing (17.4%), and Valsalva maneuver (30.4%).
    • Abnormal blood pressure responses were noted in PD patients during standing (8.7%) and sustained handgrip (21.7%).
    • Using a definition of abnormal scores on two or more tests, 23% of PD patients exhibited cardiovascular autonomic dysfunction, compared to 0% of controls.

    Conclusions:

    • The automated program effectively screens for cardiovascular autonomic dysfunction in Parkinson's disease.
    • A significant portion of ambulant PD patients demonstrate autonomic dysfunction, even without disabling fluctuations.
    • This screening method aids in identifying autonomic impairment, potentially guiding therapeutic interventions.