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[Changes in the buccal epithelium in certain diseases in children]

B Ia Ryzhavskiĭ, G N Kholodok

    Klinicheskaia Laboratornaia Diagnostika
    |March 1, 1995
    PubMed

    Insights

    This study examined buccal epitheliocytes in children aged 1-5 years. Cell size and cytolysis measurements correlated with hematological deviations in children with bronchopulmonary and somatic diseases.

    Area of Science:

    • Pediatric Medicine
    • Cell Biology
    • Clinical Diagnostics

    Background:

    • Buccal epitheliocytes offer a non-invasive method for assessing cellular health.
    • Pediatric diseases can manifest with subtle cellular changes.
    • Hematological parameters are standard indicators of child health.

    Purpose of the Study:

    • To evaluate quantitative changes in buccal epitheliocytes in children.
    • To correlate these cellular changes with hematological status in sick children.
    • To explore the diagnostic potential of buccal cell analysis.

    Main Methods:

    • Collection of buccal epitheliocytes from children aged 1-5 years (healthy and sick).
    • Measurement of maximal, minimal, and mean epitheliocyte size.
    • Estimation of the percentage of cell cytolysis.
    • Derivation of an integral index based on quantitative parameters.

    Main Results:

    • Quantitative parameters of buccal epitheliocytes were measured.
    • An integral index reflecting cellular changes was developed.
    • This index showed a positive correlation with hematological parameter deviations.
    • Findings were observed in children with bronchopulmonary and somatic diseases.

    Conclusions:

    • Quantitative analysis of buccal epitheliocytes can indicate health status in children.
    • Buccal cell morphology changes correlate with systemic health indicators.
    • This approach may aid in the early detection and monitoring of pediatric diseases.

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