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Activation of GABA-A receptor by hypotensive drugs
M Remiszewska1, Z Jastrzebski, H Czyzewska-Szafran
1Department of Pharmacology, Drug Institute, Warsaw, Poland.
Research Communications in Molecular Pathology and Pharmacology
|March 1, 1995
Abstract:
Chronic antihypertensive treatment with clonidine and beta-adrenoceptor blockers leads to a significant increase in GABA-A receptor number in the hypothalamus, the pons-medulla and the striatum. The enhancement of receptor number after two beta-blockers was associated with the decrease of Kd factor in the pons-medulla and the striatum. There was no change in receptor affinity after clonidine. We conclude that neurotransmission via GABA-A receptors is important for the hypotensive effects of clonidine and some beta-adrenoceptor blockers.