Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reorganisation in human motor cortex

M C Ridding1, J C Rothwell

  • 1Medical Research Council Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, Queen Square, London, U.K.

Canadian Journal of Physiology and Pharmacology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Somatosensory input in the context of transcranial magnetic stimulation coupled with electroencephalography: An evidence-based overview.

Neuroscience and biobehavioral reviews·2023
Same author

Only the Fastest Corticospinal Fibers Contribute to β Corticomuscular Coherence.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2021
Same author

Premovement Suppression of Corticospinal Excitability may be a Necessary Part of Movement Preparation.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Vestibulo masseteric reflex and acoustic masseteric Reflex. Normative data and effects of age and gender.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2019
Same author

A qualitative study exploring views and experiences of people with stroke undergoing transcranial direct current stimulation and upper limb robot therapy.

Topics in stroke rehabilitation·2018
Same author

Tremor in motor neuron disease may be central rather than peripheral in origin.

European journal of neurology·2018
Same journal

Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system.

Canadian journal of physiology and pharmacology·2026
Same journal

Exploring the causal relationship between inflammatory cytokines and diabetic foot ulcer: A bidirectional Mendelian randomization and clinical validation study.

Canadian journal of physiology and pharmacology·2026
Same journal

TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies.

Canadian journal of physiology and pharmacology·2026
Same journal

Association of stromal cell derived factor 1α and interferon-γ induced protein 10 with Fontan pathophysiology.

Canadian journal of physiology and pharmacology·2026
Same journal

Incretins for Type 2 Diabetes.

Canadian journal of physiology and pharmacology·2026
Same journal

Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases.

Canadian journal of physiology and pharmacology·2026
See all related articles

Cortical reorganization in motor cortex maps is observed at rest following amputation or anesthesia. However, this reorganization disappears during voluntary muscle activity, questioning its functional benefit for movement control.

Area of Science:

  • Neuroscience
  • Motor Control
  • Neuroplasticity

Background:

  • Peripheral nerve damage or anesthesia can lead to changes in the central nervous system.
  • The motor cortex's representation of muscles may reorganize in response to altered sensory input.

Purpose of the Study:

  • To investigate changes in motor cortex excitability and mapping.
  • To determine if cortical reorganization is present at rest and during voluntary contraction after peripheral alterations.

Main Methods:

  • Utilized transcranial magnetic stimulation (TMS) to map motor cortex representation.
  • Evoked electromyogram (EMG) responses in muscles proximal to amputation stumps or anesthetized forearms.
  • Compared cortical maps and responses at rest versus during tonic voluntary contraction.

Related Experiment Videos

Main Results:

  • Cortical maps were larger and responses stronger at rest when stimulating contralateral to the affected limb (amputation/anesthesia) compared to the intact limb or baseline.
  • These differences in map size and response amplitude vanished during a small voluntary contraction of the target muscle.

Conclusions:

  • Cortical reorganization of corticospinal projections to a muscle may be specific to the resting state.
  • The functional relevance of observed cortical reorganization for movement control after peripheral damage is questionable if it is absent during activity.