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Familial prolactinoma
Clinical Endocrinology
|May 1, 1995
Abstract
Background:
Apart from the rare association with type I multiple endocrine neoplasia (MEN-1), familial types of prolactinoma have not been reported.
Patients And Measurements:
Eight hyperprolactinaemic patients in four families and 18 of their first and second-degree relatives (parents, children and grandchildren) were examined. Hormone levels were measured, as well as other biochemical parameters.
Results:
Prolactinoma was diagnosed in more than one member of each of the four families.
Conclusion:
Familial prolactinoma is a distinct entity which is probably due to a genetic mutation promoting lactotroph proliferation.